Model reveals addiction to oncogenes

Cancer. Addiction to oncogenes--the Achilles heal of cancer.

Oncogenes, anti-oncogenes and the immune response to cancer: a mathematical model.

We develop a mathematical model for the initial growth of a tumour after a mutation in which either an oncogene is expressed or an anti-oncogene (i.e. tumour suppressor gene) is lost. Our model incorporates mitotic control by several biochemicals, with quite different regulatory characteristics, and we consider mutations affecting the cellular response to these control mechanisms. Our mathemati...

Choice reveals that rats are majoritarily resilient to cocaine addiction

*University Bordeaux 2, Université Bordeaux 1, CNRS, M.A.C. UMR 5227, 146 rue Léo-Saignat, 33076 Bordeaux, France Current address : University Bordeaux 2, ISPED, 146 rue Léo-Saignat, 33076 Bordeaux, France. Current address : University of Miami, Miller School of Medicine, Department of Psychiatry and Behavioral Sciences, 1600 NW 10th Ave. Miami, FL 33136 Current address : Université Bordeaux 2,...

Co-occurrence analysis of insertional mutagenesis data reveals cooperating oncogenes

MOTIVATION Cancers are caused by an accumulation of multiple independent mutations that collectively deregulate cellular pathways, e.g. such as those regulating cell division and cell-death. The publicly available Retroviral Tagged Cancer Gene Database (RTCGD) contains the data of many insertional mutagenesis screens, in which the virally induced mutations result in tumor formation in mice. The...

The Multivariate Rational Addiction Model

This paper generalizes the model of Becker, Grossman, and Murphy (1994) to the multivariate case. The multivariate model generates Frisch demand functions where current consumption is related to prices of all goods, and lagged and future consumption of all goods. The theoretical restrictions are that current price effects (holding lagged and future consumption constant) are negative definite, a...